WASHINGTON: A brand new research has discovered that the composition of the intestine microbiome helps in predicting how probably an individual will succumb to doubtlessly life-threatening an infection with Klebsiella pneumoniae, E.coli and different bugs — and it might be altered by altering your eating regimen.
The group of micro organism referred to as Enterobacteriaceae, together with Klebsiella pneumoniae, Shigella, E.coli and others, is current at low ranges as a part of a wholesome human intestine microbiome. However, sure catalytic elements resembling elevated irritation within the physique, or by consuming contaminated meals these bugs could cause sickness and illness. In excessive instances, an excessive amount of Enterobacteriaceae within the intestine could be life-threatening.
Researchers have used computational approaches together with AI to analyse the intestine microbiome composition of over 12,000 individuals throughout 45 international locations from their stool samples. They discovered that an individual’s microbiome ‘signature’ can predict whether or not an individual’s intestine is prone to be colonised by Enterobacteriaceae. The outcomes are constant throughout completely different states of well being and geographic places.
The researchers recognized 135 intestine microbe species which can be generally discovered within the absence of Enterobacteriaceae. It probably protects towards an infection. The outcomes are revealed within the journal Nature Microbiology.
Notable among the many protecting intestine species is a gaggle of micro organism referred to as Faecalibacterium, which produces useful compounds referred to as short-chain fatty acids by breaking down fibre within the meals we eat.
This appears to guard towards an infection by a spread of disease-causing Enterobacteriaceae bugs.
The researchers recommend that consuming extra fibre in our eating regimen will assist the expansion of excellent micro organism — and crowd out the unhealthy ones to considerably cut back the danger of sickness.
In distinction, taking probiotics — which do not immediately change the atmosphere within the intestine — is much less prone to have an effect on the probability of Enterobacteriaceae an infection.
“Our outcomes recommend that what we eat is doubtlessly crucial in controlling the probability of an infection with a spread of micro organism, together with E.coli and Klebsiella pneumoniae as a result of this adjustments our intestine atmosphere to make it extra hostile to invaders,” mentioned Dr Alexandre Almeida, a researcher on the University of Cambridge’s Department of Veterinary Medicine and senior creator of the paper.
He added: “By consuming fibre in meals like greens, beans and complete grains, we are able to present the uncooked materials for our intestine micro organism to supply short-chain fatty acids — compounds that may defend us from these pathogenic bugs.”
Klebsiella pneumonia could cause pneumonia, meningitis and different infections.
